Drug interactions
Ketamine + Orphenadrin
Severity: Moderate
Ketamine and Orphenadrin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketamine causes sedation and dissociation, and orphenadrine adds CNS depression and anticholinergic effects. Together they may cause deeper sedation, confusion and delirium.
What this interaction means in plain words
Ketamine and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketamine belongs to Central Nervous System; Orphenadrin belongs to Musculoskeletal.
Why it happens
Additive CNS depressant and anticholinergic effects.
What to do
Monitor level of consciousness, and reduce ketamine or orphenadrine doses if sedation is excessive. Provide supervised monitoring when ketamine is given in a procedural or anesthetic setting.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Orphenadrin
Other interactions of Ketamine
Frequently asked questions
Can I take Ketamine with Orphenadrin?
MediHelp rates the interaction as moderate. Ketamine and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketamine causes sedation and dissociation, and orphenadrine adds CNS depression and anticholinergic effects. Together they may cause deeper sedation, confusion and delirium.
How serious is the interaction between Ketamine and Orphenadrin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor level of consciousness, and reduce ketamine or orphenadrine doses if sedation is excessive. Provide supervised monitoring when ketamine is given in a procedural or anesthetic setting.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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