Drug interactions
Ketamine + Procarbazine
Severity: Moderate
Ketamine and Procarbazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has weak MAO-inhibiting activity and can cause CNS depression, so it may add to ketamine sedation. Its MAO inhibition may also potentiate sympathomimetic effects, making blood pressure changes unpredictable.
What this interaction means in plain words
Ketamine and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketamine belongs to Central Nervous System; Procarbazine belongs to Oncology.
Why it happens
Additive CNS depression; weak MAO inhibition by procarbazine may augment ketamine's sympathomimetic effects.
What to do
Use reduced ketamine doses titrated to effect and monitor blood pressure, heart rate and sedation closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketamine
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Ketamine with Procarbazine?
MediHelp rates the interaction as moderate. Ketamine and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine has weak MAO-inhibiting activity and can cause CNS depression, so it may add to ketamine sedation. Its MAO inhibition may also potentiate sympathomimetic effects, making blood pressure changes unpredictable.
How serious is the interaction between Ketamine and Procarbazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use reduced ketamine doses titrated to effect and monitor blood pressure, heart rate and sedation closely.
What other medicines interact with Ketamine?
MediHelp also lists interactions of Ketamine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine buccal. The full list is on the Ketamine page.
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