Drug interactions
Ketamine + Ramelteon
Severity: Moderate
Ketamine and Ramelteon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketamine causes dissociation and sedation, and ramelteon may add to the sedative effect. The combination matters mainly with anesthetic or procedural doses.
What this interaction means in plain words
Ketamine and Ramelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketamine belongs to Central Nervous System; Ramelteon belongs to Central Nervous System.
Why it happens
Additive CNS depression through NMDA antagonism and melatonin receptor agonism.
What to do
Monitor sedation level and vital signs when ketamine is given to patients taking ramelteon. Counsel outpatients not to drive after ketamine treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Other interactions of Ketamine
Frequently asked questions
Can I take Ketamine with Ramelteon?
MediHelp rates the interaction as moderate. Ketamine and Ramelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketamine causes dissociation and sedation, and ramelteon may add to the sedative effect. The combination matters mainly with anesthetic or procedural doses.
How serious is the interaction between Ketamine and Ramelteon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and vital signs when ketamine is given to patients taking ramelteon. Counsel outpatients not to drive after ketamine treatment.
What other medicines interact with Ramelteon?
MediHelp also lists interactions of Ramelteon with, for example, Calcium / magnesium / potassium / sodium oxybates, Fluvoxamine, Sodium oxybate. The full list is on the Ramelteon page.
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