Drug interactions
Ketamine + Secobarbital
Severity: Moderate
Ketamine and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates and ketamine together can intensify CNS and respiratory depression and may cause hypotension. Barbiturates may also reduce ketamine duration through enzyme induction.
What this interaction means in plain words
Ketamine and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketamine belongs to Central Nervous System; Secobarbital belongs to Central Nervous System.
Why it happens
Additive CNS and respiratory depression, with possible induction of ketamine metabolism.
What to do
Titrate each drug carefully and monitor respiration, oxygen saturation and blood pressure. Ensure airway support is available when used for anesthesia or sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Ketamine
Frequently asked questions
Can I take Ketamine with Secobarbital?
MediHelp rates the interaction as moderate. Ketamine and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates and ketamine together can intensify CNS and respiratory depression and may cause hypotension. Barbiturates may also reduce ketamine duration through enzyme induction.
How serious is the interaction between Ketamine and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate each drug carefully and monitor respiration, oxygen saturation and blood pressure. Ensure airway support is available when used for anesthesia or sedation.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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