Drug interactions
Ketamine + Sparsentan
Severity: Minor
Ketamine and Sparsentan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan is a weak inducer of CYP3A4 and a CYP2B6 and CYP2C9 inducer, and ketamine is metabolized by CYP2B6 and CYP3A4. Ketamine exposure may be modestly reduced, which could weaken its effect. The clinical significance is probably small.
What this interaction means in plain words
Ketamine and Sparsentan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ketamine belongs to Central Nervous System; Sparsentan belongs to Genitourinary.
Why it happens
Sparsentan induces CYP2B6 and CYP3A4, accelerating ketamine metabolism.
What to do
Monitor for reduced ketamine effect and titrate dose to clinical response. No empiric dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketamine
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Ketamine with Sparsentan?
MediHelp rates the interaction as minor. Ketamine and Sparsentan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sparsentan is a weak inducer of CYP3A4 and a CYP2B6 and CYP2C9 inducer, and ketamine is metabolized by CYP2B6 and CYP3A4. Ketamine exposure may be modestly reduced, which could weaken its effect. The clinical significance is probably small.
How serious is the interaction between Ketamine and Sparsentan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced ketamine effect and titrate dose to clinical response. No empiric dose change is needed.
What other medicines interact with Ketamine?
MediHelp also lists interactions of Ketamine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine buccal. The full list is on the Ketamine page.
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