Drug interactions
Ketamine + Thioridazine
Severity: Moderate
Ketamine and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, and thioridazine can cause hypotension through alpha-blockade. Together they may cause deeper sedation, hypotension and respiratory depression. Thioridazine can also lower the seizure threshold.
What this interaction means in plain words
Ketamine and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketamine belongs to Central Nervous System; Thioridazine belongs to Central Nervous System.
Why it happens
Additive CNS depression and hypotensive effects.
What to do
Titrate ketamine to effect and monitor blood pressure, oxygenation and level of consciousness. Provide appropriate monitored care during procedures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Ketamine
Frequently asked questions
Can I take Ketamine with Thioridazine?
MediHelp rates the interaction as moderate. Ketamine and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, and thioridazine can cause hypotension through alpha-blockade. Together they may cause deeper sedation, hypotension and respiratory depression. Thioridazine can also lower the seizure threshold.
How serious is the interaction between Ketamine and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate ketamine to effect and monitor blood pressure, oxygenation and level of consciousness. Provide appropriate monitored care during procedures.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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