Drug interactions
Ketamine + Tranylcypromine
Severity: Moderate
Ketamine and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketamine stimulates the sympathetic system and can raise blood pressure and heart rate, and with an MAO inhibitor this response may be exaggerated or unpredictable. The risk is of hypertensive episodes during anesthesia or sedation.
What this interaction means in plain words
Ketamine and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketamine belongs to Central Nervous System; Tranylcypromine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic sympathomimetic effects; ketamine releases catecholamines whose effects are potentiated by MAO inhibition.
What to do
Tell the anesthesia team about MAOI use and monitor blood pressure and heart rate continuously. Use the lowest effective ketamine dose and have antihypertensive treatment available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Ketamine
Frequently asked questions
Can I take Ketamine with Tranylcypromine?
MediHelp rates the interaction as moderate. Ketamine and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketamine stimulates the sympathetic system and can raise blood pressure and heart rate, and with an MAO inhibitor this response may be exaggerated or unpredictable. The risk is of hypertensive episodes during anesthesia or sedation.
How serious is the interaction between Ketamine and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Tell the anesthesia team about MAOI use and monitor blood pressure and heart rate continuously. Use the lowest effective ketamine dose and have antihypertensive treatment available.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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