Drug interactions
Ketamine + Voxelotor
Severity: Moderate
Ketamine and Voxelotor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor inhibits CYP3A4 and may increase exposure to ketamine, which is partly metabolized by this enzyme. This could intensify sedation, dissociative effects and cardiovascular stimulation.
What this interaction means in plain words
Ketamine and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketamine belongs to Central Nervous System; Voxelotor belongs to Miscellaneous.
Why it happens
Voxelotor inhibits CYP3A4, decreasing ketamine metabolic clearance.
What to do
Use the lowest effective ketamine dose and titrate slowly while monitoring blood pressure, heart rate and level of sedation. Lower subsequent doses if effects are exaggerated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketamine
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Ketamine with Voxelotor?
MediHelp rates the interaction as moderate. Ketamine and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voxelotor inhibits CYP3A4 and may increase exposure to ketamine, which is partly metabolized by this enzyme. This could intensify sedation, dissociative effects and cardiovascular stimulation.
How serious is the interaction between Ketamine and Voxelotor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective ketamine dose and titrate slowly while monitoring blood pressure, heart rate and level of sedation. Lower subsequent doses if effects are exaggerated.
What other medicines interact with Ketamine?
MediHelp also lists interactions of Ketamine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine buccal. The full list is on the Ketamine page.
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