Drug interactions
ketoconazole + macitentan
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
↑ macitentan exposure.
Mechanism of action
CYP3A4 inhibition.
Clinical management
Avoid or monitor for AEs.
Drug reference
References
Frequently asked questions
Can I take ketoconazole with macitentan?
The interaction is rated: Major. ↑ macitentan exposure.
How serious is the interaction between ketoconazole and macitentan?
The interaction is rated: Major. Evidence level: Moderate.
How is the interaction between ketoconazole and macitentan managed?
Avoid or monitor for AEs.
Why do ketoconazole and macitentan interact?
CYP3A4 inhibition.
Full monographs, dosing and an interaction checker in the MediHelp app
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