Drug interactions
Ketoconazole + Mavacamten
Severity: Contraindicated
Ketoconazole and Mavacamten: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole raises mavacamten exposure and may cause excessive reduction in ejection fraction leading to heart failure from systolic dysfunction. Labeling contraindicates its use with strong CYP3A4 inhibitors.
What this interaction means in plain words
Ketoconazole and Mavacamten are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ketoconazole belongs to Anti Fungals; Mavacamten belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4 and CYP2C19 reduces mavacamten metabolism.
What to do
Do not co-administer. Use an alternative antifungal and monitor echocardiographic LVEF per mavacamten labeling.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Ketoconazole with Mavacamten?
MediHelp rates the interaction as contraindicated. Ketoconazole and Mavacamten are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketoconazole raises mavacamten exposure and may cause excessive reduction in ejection fraction leading to heart failure from systolic dysfunction. Labeling contraindicates its use with strong CYP3A4 inhibitors.
How serious is the interaction between Ketoconazole and Mavacamten?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Use an alternative antifungal and monitor echocardiographic LVEF per mavacamten labeling.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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