Drug interactions
Ketoconazole + Meloxicam
Severity: Minor
Ketoconazole and Meloxicam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole inhibits CYP3A4 and may modestly inhibit CYP2C9, which can raise meloxicam exposure. This might increase the risk of NSAID adverse effects.
What this interaction means in plain words
Ketoconazole and Meloxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ketoconazole belongs to Anti Fungals; Meloxicam belongs to Musculoskeletal.
Why it happens
Inhibition of CYP3A4 and CYP2C9 metabolism of meloxicam by ketoconazole.
What to do
No routine dose change is needed; monitor for GI, renal and bleeding adverse effects and use the lowest effective dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Ketoconazole with Meloxicam?
MediHelp rates the interaction as minor. Ketoconazole and Meloxicam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ketoconazole inhibits CYP3A4 and may modestly inhibit CYP2C9, which can raise meloxicam exposure. This might increase the risk of NSAID adverse effects.
How serious is the interaction between Ketoconazole and Meloxicam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for GI, renal and bleeding adverse effects and use the lowest effective dose.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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