Drug interactions
Ketoconazole + Netupitant-palonosetron
Severity: Moderate
Ketoconazole and Netupitant-palonosetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole is a strong CYP3A4 inhibitor and increased netupitant exposure in labeled interaction studies. The label advises against dose adjustment for single-dose use but recommends caution.
What this interaction means in plain words
Ketoconazole and Netupitant-palonosetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketoconazole belongs to Anti Fungals; Netupitant-palonosetron belongs to Gastrointestinal Tract.
Why it happens
Inhibition of CYP3A4-mediated netupitant metabolism.
What to do
No dose adjustment is required for the single netupitant dose. Monitor for netupitant adverse effects such as headache, constipation and fatigue.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Netupitant-palonosetron
- Apomorphine + Netupitant-palonosetron Contraindicated
- Flibanserin + Netupitant-palonosetron Contraindicated
- Apalutamide + Netupitant-palonosetron Major
- Avapritinib + Netupitant-palonosetron Major
- Carbamazepine + Netupitant-palonosetron Major
- Cobimetinib + Netupitant-palonosetron Major
Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Ketoconazole with Netupitant-palonosetron?
MediHelp rates the interaction as moderate. Ketoconazole and Netupitant-palonosetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoconazole is a strong CYP3A4 inhibitor and increased netupitant exposure in labeled interaction studies. The label advises against dose adjustment for single-dose use but recommends caution.
How serious is the interaction between Ketoconazole and Netupitant-palonosetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required for the single netupitant dose. Monitor for netupitant adverse effects such as headache, constipation and fatigue.
What other medicines interact with Netupitant-palonosetron?
MediHelp also lists interactions of Netupitant-palonosetron with, for example, Apomorphine, Flibanserin, Apalutamide. The full list is on the Netupitant-palonosetron page.
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