Drug interactions
Ketoconazole + Praziquantel
Severity: Minor
Ketoconazole and Praziquantel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole increases praziquantel plasma concentrations, which may increase dose-related adverse effects such as dizziness, headache and gastrointestinal upset. The clinical impact is usually modest.
What this interaction means in plain words
Ketoconazole and Praziquantel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ketoconazole belongs to Anti Fungals; Praziquantel belongs to Anti Parasitic.
Why it happens
Ketoconazole inhibits CYP3A4, reducing praziquantel first-pass metabolism.
What to do
No routine dose change is needed; monitor for increased adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Other interactions of Praziquantel
- Enzalutamide + Praziquantel Contraindicated
- Praziquantel + Rifampin Contraindicated
- Amobarbital + Praziquantel Major
- Apalutamide + Praziquantel Major
- Butabarbital + Praziquantel Major
- Butalbital + Praziquantel Major
Frequently asked questions
Can I take Ketoconazole with Praziquantel?
MediHelp rates the interaction as minor. Ketoconazole and Praziquantel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ketoconazole increases praziquantel plasma concentrations, which may increase dose-related adverse effects such as dizziness, headache and gastrointestinal upset. The clinical impact is usually modest.
How serious is the interaction between Ketoconazole and Praziquantel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for increased adverse effects.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Ketoconazole page.
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