Drug interactions
Ketoprofen + Meclofenamate
Severity: Major
Ketoprofen and Meclofenamate: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Two NSAIDs taken together offer no added efficacy but increase the risk of gastrointestinal ulceration, bleeding and renal toxicity. This therapeutic duplication should generally be avoided.
What this interaction means in plain words
Ketoprofen and Meclofenamate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Duplicate COX-1/COX-2 inhibition producing additive gastrointestinal, platelet and renal prostaglandin suppression.
What to do
Avoid concurrent use of two systemic NSAIDs; choose a single agent at the lowest effective dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Frequently asked questions
Can I take Ketoprofen with Meclofenamate?
MediHelp rates the interaction as major. Ketoprofen and Meclofenamate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Two NSAIDs taken together offer no added efficacy but increase the risk of gastrointestinal ulceration, bleeding and renal toxicity. This therapeutic duplication should generally be avoided.
How serious is the interaction between Ketoprofen and Meclofenamate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two systemic NSAIDs; choose a single agent at the lowest effective dose.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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