Drug interactions
Ketoprofen + Methyclothiazide
Severity: Moderate
Ketoprofen and Methyclothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the antihypertensive and diuretic effects of thiazides and, together with diuretics, increase the risk of acute kidney injury, especially in dehydrated or elderly patients.
What this interaction means in plain words
Ketoprofen and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandins causes sodium and water retention and reduced renal perfusion, opposing the thiazide.
What to do
Monitor blood pressure, renal function and electrolytes, and ensure adequate hydration; adjust antihypertensive therapy or limit NSAID use if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Frequently asked questions
Can I take Ketoprofen with Methyclothiazide?
MediHelp rates the interaction as moderate. Ketoprofen and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the antihypertensive and diuretic effects of thiazides and, together with diuretics, increase the risk of acute kidney injury, especially in dehydrated or elderly patients.
How serious is the interaction between Ketoprofen and Methyclothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and electrolytes, and ensure adequate hydration; adjust antihypertensive therapy or limit NSAID use if control worsens.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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