Drug interactions
Ketoprofen + Mipomersen
Severity: Moderate
Ketoprofen and Mipomersen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mipomersen can cause hepatotoxicity with elevated transaminases and hepatic fat accumulation, and NSAIDs may occasionally raise liver enzymes. Combined use may add to hepatic risk.
What this interaction means in plain words
Ketoprofen and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive potential hepatotoxicity; no pharmacokinetic interaction is established.
What to do
Monitor ALT, AST and bilirubin per mipomersen labeling and stop the offending drug if enzymes rise significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Frequently asked questions
Can I take Ketoprofen with Mipomersen?
MediHelp rates the interaction as moderate. Ketoprofen and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mipomersen can cause hepatotoxicity with elevated transaminases and hepatic fat accumulation, and NSAIDs may occasionally raise liver enzymes. Combined use may add to hepatic risk.
How serious is the interaction between Ketoprofen and Mipomersen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ALT, AST and bilirubin per mipomersen labeling and stop the offending drug if enzymes rise significantly.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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