Drug interactions
Ketoprofen + Mycophenolate
Severity: Moderate
Ketoprofen and Mycophenolate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoprofen and the mycophenolic acid glucuronide metabolite may compete for renal tubular secretion, potentially raising mycophenolate exposure. NSAIDs can also add to gastrointestinal toxicity and impair renal function in transplant patients.
What this interaction means in plain words
Ketoprofen and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition for renal tubular secretion of acyl glucuronides and additive GI mucosal toxicity.
What to do
Monitor for mycophenolate adverse effects such as GI upset and cytopenias, and renal function; avoid regular NSAID use in transplant recipients when possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Frequently asked questions
Can I take Ketoprofen with Mycophenolate?
MediHelp rates the interaction as moderate. Ketoprofen and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoprofen and the mycophenolic acid glucuronide metabolite may compete for renal tubular secretion, potentially raising mycophenolate exposure. NSAIDs can also add to gastrointestinal toxicity and impair renal function in transplant patients.
How serious is the interaction between Ketoprofen and Mycophenolate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mycophenolate adverse effects such as GI upset and cytopenias, and renal function; avoid regular NSAID use in transplant recipients when possible.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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