Drug interactions
Ketoprofen + Neomycin po
Severity: Minor
Ketoprofen and Neomycin po: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral neomycin is poorly absorbed, so systemic exposure is minimal in most patients. NSAID-related reductions in renal clearance of aminoglycosides have been described mainly in preterm infants receiving parenteral drugs, so relevance here is very limited.
What this interaction means in plain words
Ketoprofen and Neomycin po have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
NSAID reduction of renal prostaglandin-mediated clearance of aminoglycosides, relevant only if systemic absorption occurs.
What to do
No action is usually needed; if used with renal impairment, damaged gut mucosa or prolonged therapy, monitor renal function and consider hearing assessment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Frequently asked questions
Can I take Ketoprofen with Neomycin po?
MediHelp rates the interaction as minor. Ketoprofen and Neomycin po have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral neomycin is poorly absorbed, so systemic exposure is minimal in most patients. NSAID-related reductions in renal clearance of aminoglycosides have been described mainly in preterm infants receiving parenteral drugs, so relevance here is very limited.
How serious is the interaction between Ketoprofen and Neomycin po?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is usually needed; if used with renal impairment, damaged gut mucosa or prolonged therapy, monitor renal function and consider hearing assessment.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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