Drug interactions
Ketoprofen + Olmesartan
Severity: Moderate
Ketoprofen and Olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can weaken the blood pressure lowering effect of angiotensin receptor blockers and, together with them, can impair renal function, especially in elderly or volume-depleted patients. Hyperkalemia may also occur.
What this interaction means in plain words
Ketoprofen and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketoprofen belongs to Musculoskeletal; Olmesartan belongs to Cardiovascular.
Why it happens
NSAIDs reduce afferent arteriolar vasodilating prostaglandins while ARBs dilate the efferent arteriole, lowering glomerular filtration pressure; reduced prostaglandin-mediated renin and aldosterone effects also favor potassium retention.
What to do
Ensure adequate hydration and monitor serum creatinine, potassium and blood pressure after starting the NSAID. Avoid in dehydrated or renally impaired patients where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Frequently asked questions
Can I take Ketoprofen with Olmesartan?
MediHelp rates the interaction as moderate. Ketoprofen and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can weaken the blood pressure lowering effect of angiotensin receptor blockers and, together with them, can impair renal function, especially in elderly or volume-depleted patients. Hyperkalemia may also occur.
How serious is the interaction between Ketoprofen and Olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and monitor serum creatinine, potassium and blood pressure after starting the NSAID. Avoid in dehydrated or renally impaired patients where possible.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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