Drug interactions
Ketoprofen + Parecoxib
Severity: Major
Ketoprofen and Parecoxib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoprofen is a non-selective NSAID and parecoxib is a prodrug of the COX-2 inhibitor valdecoxib. Taking both gives no added therapeutic benefit and increases the risk of gastrointestinal bleeding or ulceration, renal impairment, fluid retention and hyperkalemia.
What this interaction means in plain words
Ketoprofen and Parecoxib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Duplicate cyclooxygenase inhibition causes additive reduction in prostaglandin synthesis, with additive effects on platelets, gastric mucosa and renal function.
What to do
Avoid combining two NSAIDs and use a single agent at the lowest effective dose. If the combination was given, monitor for GI bleeding, renal function and serum potassium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Frequently asked questions
Can I take Ketoprofen with Parecoxib?
MediHelp rates the interaction as major. Ketoprofen and Parecoxib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ketoprofen is a non-selective NSAID and parecoxib is a prodrug of the COX-2 inhibitor valdecoxib. Taking both gives no added therapeutic benefit and increases the risk of gastrointestinal bleeding or ulceration, renal impairment, fluid retention and hyperkalemia.
How serious is the interaction between Ketoprofen and Parecoxib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two NSAIDs and use a single agent at the lowest effective dose. If the combination was given, monitor for GI bleeding, renal function and serum potassium.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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