Drug interactions
Ketoprofen + Penbutolol
Severity: Moderate
Ketoprofen and Penbutolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoprofen may blunt the blood pressure lowering effect of penbutolol, especially with continued use. Rises in blood pressure may be seen, and renal function and potassium can be affected in susceptible patients.
What this interaction means in plain words
Ketoprofen and Penbutolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAIDs inhibit vasodilatory renal and vascular prostaglandins, causing sodium and water retention that opposes the antihypertensive action of beta-blockers.
What to do
Monitor blood pressure when starting, stopping or changing the NSAID dose, and adjust the antihypertensive regimen if needed. Use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Frequently asked questions
Can I take Ketoprofen with Penbutolol?
MediHelp rates the interaction as moderate. Ketoprofen and Penbutolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoprofen may blunt the blood pressure lowering effect of penbutolol, especially with continued use. Rises in blood pressure may be seen, and renal function and potassium can be affected in susceptible patients.
How serious is the interaction between Ketoprofen and Penbutolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when starting, stopping or changing the NSAID dose, and adjust the antihypertensive regimen if needed. Use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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