Drug interactions
Ketoprofen + Phenindione
Severity: Major
Ketoprofen and Phenindione: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenindione is a vitamin K antagonist, and ketoprofen impairs platelet function and can cause gastrointestinal bleeding. Combined use significantly raises the risk of serious hemorrhage, and NSAIDs may also displace anticoagulants from protein binding.
What this interaction means in plain words
Ketoprofen and Phenindione can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive hemostatic impairment from anticoagulation and NSAID platelet inhibition and mucosal injury, with possible protein-binding displacement.
What to do
Avoid the combination and choose paracetamol if possible; if unavoidable, monitor INR closely, watch for bleeding and consider gastroprotection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Frequently asked questions
Can I take Ketoprofen with Phenindione?
MediHelp rates the interaction as major. Ketoprofen and Phenindione can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Phenindione is a vitamin K antagonist, and ketoprofen impairs platelet function and can cause gastrointestinal bleeding. Combined use significantly raises the risk of serious hemorrhage, and NSAIDs may also displace anticoagulants from protein binding.
How serious is the interaction between Ketoprofen and Phenindione?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose paracetamol if possible; if unavoidable, monitor INR closely, watch for bleeding and consider gastroprotection.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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