Drug interactions
Ketoprofen + Phenoxybenzamine
Severity: Minor
Ketoprofen and Phenoxybenzamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoprofen may reduce the blood pressure lowering effect of phenoxybenzamine through fluid retention and loss of vasodilatory prostaglandins. The clinical effect is usually modest but can matter in patients being prepared for surgery for pheochromocytoma.
What this interaction means in plain words
Ketoprofen and Phenoxybenzamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
NSAID inhibition of vasodilatory prostaglandin synthesis with sodium and water retention opposes alpha-blockade.
What to do
Monitor blood pressure when an NSAID is started or stopped and titrate phenoxybenzamine as needed. Consider acetaminophen as an alternative analgesic.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Frequently asked questions
Can I take Ketoprofen with Phenoxybenzamine?
MediHelp rates the interaction as minor. Ketoprofen and Phenoxybenzamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ketoprofen may reduce the blood pressure lowering effect of phenoxybenzamine through fluid retention and loss of vasodilatory prostaglandins. The clinical effect is usually modest but can matter in patients being prepared for surgery for pheochromocytoma.
How serious is the interaction between Ketoprofen and Phenoxybenzamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when an NSAID is started or stopped and titrate phenoxybenzamine as needed. Consider acetaminophen as an alternative analgesic.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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