Drug interactions
Ketoprofen + Pindolol
Severity: Moderate
Ketoprofen and Pindolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoprofen can weaken the antihypertensive effect of pindolol, particularly with continued use beyond a week or so. Blood pressure may rise, and renal function and potassium may also be affected.
What this interaction means in plain words
Ketoprofen and Pindolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal and vascular prostaglandins causes sodium and water retention and counteracts beta-blocker blood pressure lowering.
What to do
Monitor blood pressure when the NSAID is started, stopped or changed, and adjust the antihypertensive dose if needed. Use the lowest effective NSAID dose for the shortest duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Frequently asked questions
Can I take Ketoprofen with Pindolol?
MediHelp rates the interaction as moderate. Ketoprofen and Pindolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketoprofen can weaken the antihypertensive effect of pindolol, particularly with continued use beyond a week or so. Blood pressure may rise, and renal function and potassium may also be affected.
How serious is the interaction between Ketoprofen and Pindolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when the NSAID is started, stopped or changed, and adjust the antihypertensive dose if needed. Use the lowest effective NSAID dose for the shortest duration.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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