Drug interactions
Ketoprofen + Propranolol
Severity: Moderate
Ketoprofen and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regular NSAID use can attenuate the blood pressure lowering effect of propranolol. Blood pressure may rise and renal function may be affected with prolonged use.
What this interaction means in plain words
Ketoprofen and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketoprofen belongs to Musculoskeletal; Propranolol belongs to Cardiovascular.
Why it happens
NSAID inhibition of prostaglandin synthesis causes sodium and water retention and vasoconstriction, opposing the beta-blocker.
What to do
Monitor blood pressure when NSAID therapy is started or stopped and titrate propranolol as needed. Limit NSAID duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Frequently asked questions
Can I take Ketoprofen with Propranolol?
MediHelp rates the interaction as moderate. Ketoprofen and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Regular NSAID use can attenuate the blood pressure lowering effect of propranolol. Blood pressure may rise and renal function may be affected with prolonged use.
How serious is the interaction between Ketoprofen and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when NSAID therapy is started or stopped and titrate propranolol as needed. Limit NSAID duration.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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