Drug interactions
Ketoprofen + Reteplase
Severity: Major
Ketoprofen and Reteplase: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Reteplase is a thrombolytic that carries a major bleeding risk, and ketoprofen inhibits platelet function and can cause gastrointestinal lesions. Concomitant use may increase the likelihood or severity of hemorrhage.
What this interaction means in plain words
Ketoprofen and Reteplase can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Fibrinolysis combined with NSAID-induced platelet dysfunction and mucosal injury produces additive bleeding risk.
What to do
Avoid starting NSAIDs around thrombolytic therapy unless clearly necessary. Monitor closely for bleeding, including at puncture sites and in the GI tract.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Frequently asked questions
Can I take Ketoprofen with Reteplase?
MediHelp rates the interaction as major. Ketoprofen and Reteplase can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Reteplase is a thrombolytic that carries a major bleeding risk, and ketoprofen inhibits platelet function and can cause gastrointestinal lesions. Concomitant use may increase the likelihood or severity of hemorrhage.
How serious is the interaction between Ketoprofen and Reteplase?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid starting NSAIDs around thrombolytic therapy unless clearly necessary. Monitor closely for bleeding, including at puncture sites and in the GI tract.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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