Drug interactions
Ketoprofen + Sacubitril / valsartan
Severity: Major
Ketoprofen and Sacubitril / valsartan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoprofen can reduce the antihypertensive and heart failure benefits of sacubitril/valsartan and increase the risk of acute kidney injury, particularly in elderly, volume-depleted or renally impaired patients. Hyperkalemia may also occur.
What this interaction means in plain words
Ketoprofen and Sacubitril / valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
NSAIDs constrict the afferent arteriole by blocking prostaglandins while angiotensin receptor blockade dilates the efferent arteriole, reducing glomerular filtration and potassium excretion.
What to do
Avoid regular NSAID use where possible and use acetaminophen instead. If combined, monitor blood pressure, serum creatinine and potassium, and ensure adequate hydration.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Frequently asked questions
Can I take Ketoprofen with Sacubitril / valsartan?
MediHelp rates the interaction as major. Ketoprofen and Sacubitril / valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ketoprofen can reduce the antihypertensive and heart failure benefits of sacubitril/valsartan and increase the risk of acute kidney injury, particularly in elderly, volume-depleted or renally impaired patients. Hyperkalemia may also occur.
How serious is the interaction between Ketoprofen and Sacubitril / valsartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use where possible and use acetaminophen instead. If combined, monitor blood pressure, serum creatinine and potassium, and ensure adequate hydration.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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