Drug interactions
Ketoprofen + Salicylates
Severity: Moderate
Ketoprofen and Salicylates: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-acetylated salicylates combined with ketoprofen duplicate NSAID therapy, raising the risk of gastrointestinal irritation, renal effects and bleeding without added benefit. Fluid retention and hyperkalemia are also possible.
What this interaction means in plain words
Ketoprofen and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive cyclooxygenase inhibition and reduced prostaglandin-mediated gastric and renal protection.
What to do
Avoid concurrent use of multiple NSAIDs or salicylates. If unavoidable, monitor for GI bleeding, renal function and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Frequently asked questions
Can I take Ketoprofen with Salicylates?
MediHelp rates the interaction as moderate. Ketoprofen and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Non-acetylated salicylates combined with ketoprofen duplicate NSAID therapy, raising the risk of gastrointestinal irritation, renal effects and bleeding without added benefit. Fluid retention and hyperkalemia are also possible.
How serious is the interaction between Ketoprofen and Salicylates?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of multiple NSAIDs or salicylates. If unavoidable, monitor for GI bleeding, renal function and potassium.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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