Drug interactions
Ketoprofen + Sodium sulfate / ?magnesium sulfate / potassium chloride
Severity: Moderate
Ketoprofen and Sodium sulfate / ?magnesium sulfate / potassium chloride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bowel preparations can cause fluid and electrolyte abnormalities, and ketoprofen can impair renal perfusion and cause water retention. The combination may increase the risk of renal injury, arrhythmias and seizures from electrolyte disturbance.
What this interaction means in plain words
Ketoprofen and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Bowel-prep-induced volume and electrolyte changes are compounded by NSAID reduction of renal prostaglandin-dependent perfusion and water handling.
What to do
Avoid NSAIDs around the time of bowel preparation when possible and ensure adequate hydration. Monitor electrolytes and renal function in at-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Frequently asked questions
Can I take Ketoprofen with Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates the interaction as moderate. Ketoprofen and Sodium sulfate / ?magnesium sulfate / potassium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bowel preparations can cause fluid and electrolyte abnormalities, and ketoprofen can impair renal perfusion and cause water retention. The combination may increase the risk of renal injury, arrhythmias and seizures from electrolyte disturbance.
How serious is the interaction between Ketoprofen and Sodium sulfate / ?magnesium sulfate / potassium chloride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid NSAIDs around the time of bowel preparation when possible and ensure adequate hydration. Monitor electrolytes and renal function in at-risk patients.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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