Drug interactions
Ketoprofen + Sodium sulfate / potassium sulfate / magnesium sulfate
Severity: Moderate
Ketoprofen and Sodium sulfate / potassium sulfate / magnesium sulfate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfate-based bowel preparations cause fluid and electrolyte disturbances, and ketoprofen can reduce renal perfusion. The combination may increase risk of acute kidney injury, arrhythmia and seizures.
What this interaction means in plain words
Ketoprofen and Sodium sulfate / potassium sulfate / magnesium sulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Volume depletion and electrolyte shifts from bowel cleansing combine with NSAID inhibition of renal prostaglandins.
What to do
Avoid NSAIDs on the day of bowel preparation when possible and maintain hydration. Monitor electrolytes and renal function in patients with kidney disease or other risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Frequently asked questions
Can I take Ketoprofen with Sodium sulfate / potassium sulfate / magnesium sulfate?
MediHelp rates the interaction as moderate. Ketoprofen and Sodium sulfate / potassium sulfate / magnesium sulfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfate-based bowel preparations cause fluid and electrolyte disturbances, and ketoprofen can reduce renal perfusion. The combination may increase risk of acute kidney injury, arrhythmia and seizures.
How serious is the interaction between Ketoprofen and Sodium sulfate / potassium sulfate / magnesium sulfate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid NSAIDs on the day of bowel preparation when possible and maintain hydration. Monitor electrolytes and renal function in patients with kidney disease or other risk factors.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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