Drug interactions
Ketoprofen + Sulfasalazine
Severity: Minor
Ketoprofen and Sulfasalazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfasalazine contains a salicylate moiety (5-aminosalicylic acid) and can occasionally cause blood disorders, while ketoprofen impairs platelet function and irritates the GI tract. Combined use may modestly increase bleeding or GI risk, and NSAIDs may worsen colitis in some patients.
What this interaction means in plain words
Ketoprofen and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive effects on GI mucosa and platelet function; NSAID prostaglandin inhibition may also affect renal potassium handling.
What to do
Monitor for GI symptoms, bleeding and changes in blood counts, and watch for flares of inflammatory bowel disease. Use the lowest effective NSAID dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Frequently asked questions
Can I take Ketoprofen with Sulfasalazine?
MediHelp rates the interaction as minor. Ketoprofen and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfasalazine contains a salicylate moiety (5-aminosalicylic acid) and can occasionally cause blood disorders, while ketoprofen impairs platelet function and irritates the GI tract. Combined use may modestly increase bleeding or GI risk, and NSAIDs may worsen colitis in some patients.
How serious is the interaction between Ketoprofen and Sulfasalazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for GI symptoms, bleeding and changes in blood counts, and watch for flares of inflammatory bowel disease. Use the lowest effective NSAID dose.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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