Drug interactions
Ketoprofen + Telmisartan
Severity: Moderate
Ketoprofen and Telmisartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can weaken the antihypertensive action of telmisartan and, together with it, may impair kidney function, particularly in the elderly or volume-depleted. Hyperkalemia is also possible.
What this interaction means in plain words
Ketoprofen and Telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketoprofen belongs to Musculoskeletal; Telmisartan belongs to Cardiovascular.
Why it happens
NSAID reduction of vasodilatory renal prostaglandins combined with ARB efferent arteriolar dilation lowers glomerular filtration and favors potassium retention.
What to do
Maintain hydration and monitor creatinine, potassium and blood pressure after starting or changing the NSAID. Avoid in volume-depleted or renally impaired patients where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Telmisartan
- Aliskiren + Telmisartan Contraindicated
- Sparsentan + Telmisartan Contraindicated
- Amifostine + Telmisartan Major
- Amiloride + Telmisartan Major
- Amlodipine-benazepril + Telmisartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Telmisartan Major
Frequently asked questions
Can I take Ketoprofen with Telmisartan?
MediHelp rates the interaction as moderate. Ketoprofen and Telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can weaken the antihypertensive action of telmisartan and, together with it, may impair kidney function, particularly in the elderly or volume-depleted. Hyperkalemia is also possible.
How serious is the interaction between Ketoprofen and Telmisartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Maintain hydration and monitor creatinine, potassium and blood pressure after starting or changing the NSAID. Avoid in volume-depleted or renally impaired patients where possible.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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