Drug interactions
Ketoprofen + Temocillin
Severity: Minor
Ketoprofen and Temocillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoprofen may reduce tubular secretion of penicillins such as temocillin and compete for protein binding, which could modestly increase temocillin exposure. The clinical relevance is typically small.
What this interaction means in plain words
Ketoprofen and Temocillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular organic anion transporters and protein binding sites reduces penicillin clearance.
What to do
No routine adjustment is needed. Monitor renal function in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Frequently asked questions
Can I take Ketoprofen with Temocillin?
MediHelp rates the interaction as minor. Ketoprofen and Temocillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ketoprofen may reduce tubular secretion of penicillins such as temocillin and compete for protein binding, which could modestly increase temocillin exposure. The clinical relevance is typically small.
How serious is the interaction between Ketoprofen and Temocillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor renal function in patients with renal impairment.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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