Drug interactions
Ketoprofen + Tenofovir df
Severity: Moderate
Ketoprofen and Tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir is cleared by the kidney, and NSAIDs may reduce renal perfusion and compete for tubular secretion. This can increase tenofovir exposure and raise the risk of renal tubular toxicity.
What this interaction means in plain words
Ketoprofen and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID-induced reduction in renal perfusion plus competition for tubular secretion increases tenofovir exposure.
What to do
Prefer paracetamol or other non-NSAID analgesia; if ketoprofen is needed, use the lowest dose briefly and monitor serum creatinine and phosphate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Frequently asked questions
Can I take Ketoprofen with Tenofovir df?
MediHelp rates the interaction as moderate. Ketoprofen and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tenofovir is cleared by the kidney, and NSAIDs may reduce renal perfusion and compete for tubular secretion. This can increase tenofovir exposure and raise the risk of renal tubular toxicity.
How serious is the interaction between Ketoprofen and Tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer paracetamol or other non-NSAID analgesia; if ketoprofen is needed, use the lowest dose briefly and monitor serum creatinine and phosphate.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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