Drug interactions
Ketoprofen + Ticarcillin
Severity: Minor
Ketoprofen and Ticarcillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoprofen may reduce renal tubular secretion of ticarcillin and compete for protein binding, possibly raising ticarcillin levels. Ticarcillin also impairs platelet function at high doses, so bleeding risk may be slightly increased with an NSAID.
What this interaction means in plain words
Ketoprofen and Ticarcillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular organic anion transport and protein binding, plus additive platelet effects.
What to do
No routine dose change is needed. Monitor for bleeding and renal function in patients on high-dose ticarcillin or with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Frequently asked questions
Can I take Ketoprofen with Ticarcillin?
MediHelp rates the interaction as minor. Ketoprofen and Ticarcillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ketoprofen may reduce renal tubular secretion of ticarcillin and compete for protein binding, possibly raising ticarcillin levels. Ticarcillin also impairs platelet function at high doses, so bleeding risk may be slightly increased with an NSAID.
How serious is the interaction between Ketoprofen and Ticarcillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for bleeding and renal function in patients on high-dose ticarcillin or with renal impairment.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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