Drug interactions
Ketoprofen + Triamcinolone acetonide injectable
Severity: Moderate
Ketoprofen and Triamcinolone acetonide injectable: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an NSAID with a systemic corticosteroid raises the likelihood of gastric irritation, peptic ulceration and gastrointestinal bleeding. The risk is greater in older patients, those with prior ulcer disease, and with prolonged or high-dose use.
What this interaction means in plain words
Ketoprofen and Triamcinolone acetonide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive gastrointestinal mucosal injury: NSAIDs reduce protective prostaglandins while corticosteroids impair mucosal healing.
What to do
Use the lowest effective doses for the shortest time and consider a proton pump inhibitor in higher-risk patients. Monitor for dyspepsia, melena or other signs of GI bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Frequently asked questions
Can I take Ketoprofen with Triamcinolone acetonide injectable?
MediHelp rates the interaction as moderate. Ketoprofen and Triamcinolone acetonide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an NSAID with a systemic corticosteroid raises the likelihood of gastric irritation, peptic ulceration and gastrointestinal bleeding. The risk is greater in older patients, those with prior ulcer disease, and with prolonged or high-dose use.
How serious is the interaction between Ketoprofen and Triamcinolone acetonide injectable?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest time and consider a proton pump inhibitor in higher-risk patients. Monitor for dyspepsia, melena or other signs of GI bleeding.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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