Drug interactions
Ketoprofen + Venlafaxine
Severity: Moderate
Ketoprofen and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Venlafaxine impairs platelet serotonin uptake and, with an NSAID, increases the risk of gastrointestinal and other bleeding. The effect is clinically important in older patients and those with ulcer history.
What this interaction means in plain words
Ketoprofen and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketoprofen belongs to Musculoskeletal; Venlafaxine belongs to Central Nervous System.
Why it happens
Serotonin reuptake inhibition depletes platelet serotonin, adding to NSAID COX-1 platelet inhibition and gastric mucosal damage.
What to do
Monitor for bleeding signs and consider gastroprotection with a proton pump inhibitor in at-risk patients. Use the lowest effective NSAID dose for the shortest duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Frequently asked questions
Can I take Ketoprofen with Venlafaxine?
MediHelp rates the interaction as moderate. Ketoprofen and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Venlafaxine impairs platelet serotonin uptake and, with an NSAID, increases the risk of gastrointestinal and other bleeding. The effect is clinically important in older patients and those with ulcer history.
How serious is the interaction between Ketoprofen and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding signs and consider gastroprotection with a proton pump inhibitor in at-risk patients. Use the lowest effective NSAID dose for the shortest duration.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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