Drug interactions
Ketorolac + Levofloxacin
Severity: Moderate
Ketorolac and Levofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may enhance the seizure-provoking potential of fluoroquinolones, increasing CNS stimulation and convulsions in susceptible patients. Risk is higher with epilepsy, renal impairment or high doses.
What this interaction means in plain words
Ketorolac and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketorolac belongs to Musculoskeletal; Levofloxacin belongs to Anti Bacterial.
Why it happens
Fluoroquinolone inhibition of GABA binding at GABA-A receptors may be potentiated by NSAIDs, lowering seizure threshold.
What to do
Avoid in patients with seizure disorders or lowered seizure threshold; otherwise use the lowest effective doses and monitor for CNS stimulation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Frequently asked questions
Can I take Ketorolac with Levofloxacin?
MediHelp rates the interaction as moderate. Ketorolac and Levofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may enhance the seizure-provoking potential of fluoroquinolones, increasing CNS stimulation and convulsions in susceptible patients. Risk is higher with epilepsy, renal impairment or high doses.
How serious is the interaction between Ketorolac and Levofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with seizure disorders or lowered seizure threshold; otherwise use the lowest effective doses and monitor for CNS stimulation.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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