Drug interactions
Ketorolac + Neomycin
Severity: Minor
Ketorolac and Neomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac can impair renal function and reduce aminoglycoside clearance, with added nephrotoxic potential. Oral neomycin is poorly absorbed, so the risk is limited, but it rises with renal impairment, inflamed bowel or prolonged use.
What this interaction means in plain words
Ketorolac and Neomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ketorolac belongs to Musculoskeletal; Neomycin belongs to Anti Bacterial.
Why it happens
Prostaglandin inhibition reduces renal perfusion and filtration, slowing elimination of absorbed neomycin and adding to nephrotoxicity.
What to do
Monitor renal function if both are used for more than a short period or in renal impairment. Avoid combining where possible in neonates or patients with kidney disease.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Neomycin
- Amikacin + Neomycin Major
- Amphotericin b deoxycholate + Neomycin Major
- Capreomycin + Neomycin Major
- Cidofovir + Neomycin Major
- Colistin + Neomycin Major
- Ethacrynic acid + Neomycin Major
Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Frequently asked questions
Can I take Ketorolac with Neomycin?
MediHelp rates the interaction as minor. Ketorolac and Neomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ketorolac can impair renal function and reduce aminoglycoside clearance, with added nephrotoxic potential. Oral neomycin is poorly absorbed, so the risk is limited, but it rises with renal impairment, inflamed bowel or prolonged use.
How serious is the interaction between Ketorolac and Neomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function if both are used for more than a short period or in renal impairment. Avoid combining where possible in neonates or patients with kidney disease.
What other medicines interact with Neomycin?
MediHelp also lists interactions of Neomycin with, for example, Amikacin, Amphotericin b deoxycholate, Capreomycin. The full list is on the Neomycin page.
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