Drug interactions
Ketorolac + Phentolamine
Severity: Minor
Ketorolac and Phentolamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the blood pressure lowering effect of vasodilating and antihypertensive drugs. Evidence for phentolamine specifically is limited, and the effect is mostly predicted.
What this interaction means in plain words
Ketorolac and Phentolamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ketorolac belongs to Musculoskeletal; Phentolamine belongs to Cardiovascular.
Why it happens
NSAID inhibition of vasodilatory prostaglandin synthesis and sodium and water retention may partly offset alpha-blocker vasodilation.
What to do
Monitor blood pressure when ketorolac is started or stopped in patients receiving phentolamine for hypertension, and adjust the phentolamine dose if response is reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Other interactions of Phentolamine
Frequently asked questions
Can I take Ketorolac with Phentolamine?
MediHelp rates the interaction as minor. Ketorolac and Phentolamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs can blunt the blood pressure lowering effect of vasodilating and antihypertensive drugs. Evidence for phentolamine specifically is limited, and the effect is mostly predicted.
How serious is the interaction between Ketorolac and Phentolamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when ketorolac is started or stopped in patients receiving phentolamine for hypertension, and adjust the phentolamine dose if response is reduced.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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