Drug interactions
Ketorolac + Pralatrexate
Severity: Moderate
Ketorolac and Pralatrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may reduce the renal elimination of pralatrexate, raising its exposure and the risk of mucositis, myelosuppression and other toxicity. Ketorolac also reduces renal blood flow, which could further impair clearance.
What this interaction means in plain words
Ketorolac and Pralatrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ketorolac belongs to Musculoskeletal; Pralatrexate belongs to Oncology.
Why it happens
Competition for renal tubular secretion and NSAID-related reduction in renal perfusion decrease pralatrexate clearance.
What to do
Avoid ketorolac around pralatrexate infusions where possible, or monitor renal function, blood counts and mucositis closely and reduce the pralatrexate dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Other interactions of Pralatrexate
Frequently asked questions
Can I take Ketorolac with Pralatrexate?
MediHelp rates the interaction as moderate. Ketorolac and Pralatrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may reduce the renal elimination of pralatrexate, raising its exposure and the risk of mucositis, myelosuppression and other toxicity. Ketorolac also reduces renal blood flow, which could further impair clearance.
How serious is the interaction between Ketorolac and Pralatrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ketorolac around pralatrexate infusions where possible, or monitor renal function, blood counts and mucositis closely and reduce the pralatrexate dose if toxicity appears.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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