Drug interactions
Ketorolac + Sparsentan
Severity: Major
Ketorolac and Sparsentan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan lowers intraglomerular pressure through endothelin and angiotensin receptor blockade, and NSAIDs reduce renal prostaglandins. Together they can cause deterioration of renal function and may reduce blood pressure control. Ketorolac carries a notable renal risk.
What this interaction means in plain words
Ketorolac and Sparsentan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ketorolac belongs to Musculoskeletal; Sparsentan belongs to Genitourinary.
Why it happens
Combined loss of prostaglandin-mediated afferent vasodilation and efferent dilation from receptor blockade lowers glomerular filtration.
What to do
Avoid ketorolac with sparsentan and use paracetamol instead. If an NSAID is unavoidable, monitor serum creatinine and potassium and blood pressure closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Ketorolac with Sparsentan?
MediHelp rates the interaction as major. Ketorolac and Sparsentan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sparsentan lowers intraglomerular pressure through endothelin and angiotensin receptor blockade, and NSAIDs reduce renal prostaglandins. Together they can cause deterioration of renal function and may reduce blood pressure control. Ketorolac carries a notable renal risk.
How serious is the interaction between Ketorolac and Sparsentan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ketorolac with sparsentan and use paracetamol instead. If an NSAID is unavoidable, monitor serum creatinine and potassium and blood pressure closely.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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