Drug interactions
Ketorolac + Voclosporin
Severity: Major
Ketorolac and Voclosporin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin, a calcineurin inhibitor, can cause dose-related reductions in glomerular filtration rate. Ketorolac further compromises renal perfusion, so the combination raises the risk of acute kidney injury.
What this interaction means in plain words
Ketorolac and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ketorolac belongs to Musculoskeletal; Voclosporin belongs to Miscellaneous.
Why it happens
Additive renal vasoconstriction: calcineurin inhibitor afferent arteriolar constriction plus NSAID inhibition of vasodilatory prostaglandins.
What to do
Avoid ketorolac where possible and use a non-NSAID analgesic. If used, keep treatment brief and monitor eGFR and serum creatinine closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Ketorolac with Voclosporin?
MediHelp rates the interaction as major. Ketorolac and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voclosporin, a calcineurin inhibitor, can cause dose-related reductions in glomerular filtration rate. Ketorolac further compromises renal perfusion, so the combination raises the risk of acute kidney injury.
How serious is the interaction between Ketorolac and Voclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ketorolac where possible and use a non-NSAID analgesic. If used, keep treatment brief and monitor eGFR and serum creatinine closely.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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