Drug interactions
Ketorolac intranasal + Mefenamic acid
Severity: Contraindicated
Ketorolac intranasal and Mefenamic acid: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefenamic acid taken with intranasal ketorolac duplicates NSAID therapy, raising the risk of gastrointestinal ulceration and bleeding, renal injury and cardiovascular events. There is no added analgesic advantage.
What this interaction means in plain words
Ketorolac intranasal and Mefenamic acid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive cyclooxygenase inhibition producing additive gastrointestinal, renal, platelet and cardiovascular toxicity.
What to do
Avoid concurrent use and keep to one NSAID. Switch to a non-NSAID adjunct if needed.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Mefenamic acid
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
- Amiloride + Mefenamic acid Major
Frequently asked questions
Can I take Ketorolac intranasal with Mefenamic acid?
MediHelp rates the interaction as contraindicated. Ketorolac intranasal and Mefenamic acid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Mefenamic acid taken with intranasal ketorolac duplicates NSAID therapy, raising the risk of gastrointestinal ulceration and bleeding, renal injury and cardiovascular events. There is no added analgesic advantage.
How serious is the interaction between Ketorolac intranasal and Mefenamic acid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and keep to one NSAID. Switch to a non-NSAID adjunct if needed.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac, Aceclofenac, Acemetacin. The full list is on the Mefenamic acid page.
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