Drug interactions
Ketorolac intranasal + Mesalamine
Severity: Moderate
Ketorolac intranasal and Mesalamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac is a potent NSAID with a well-known risk of acute kidney injury, and intranasal dosing still gives systemic exposure. Combined with mesalamine, which can cause interstitial nephritis, renal risk may be increased.
What this interaction means in plain words
Ketorolac intranasal and Mesalamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity from prostaglandin inhibition by ketorolac plus tubulointerstitial toxicity of mesalamine.
What to do
Keep ketorolac courses short and monitor serum creatinine, particularly in patients who are dehydrated or have renal disease. Consider a non-NSAID analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mesalamine
Frequently asked questions
Can I take Ketorolac intranasal with Mesalamine?
MediHelp rates the interaction as moderate. Ketorolac intranasal and Mesalamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketorolac is a potent NSAID with a well-known risk of acute kidney injury, and intranasal dosing still gives systemic exposure. Combined with mesalamine, which can cause interstitial nephritis, renal risk may be increased.
How serious is the interaction between Ketorolac intranasal and Mesalamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep ketorolac courses short and monitor serum creatinine, particularly in patients who are dehydrated or have renal disease. Consider a non-NSAID analgesic.
What other medicines interact with Mesalamine?
MediHelp also lists interactions of Mesalamine with, for example, Measles mumps rubella and varicella vaccine live, Varicella virus vaccine live, Aceclofenac. The full list is on the Mesalamine page.
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