Drug interactions
Ketorolac intranasal + Neomycin
Severity: Minor
Ketorolac intranasal and Neomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce aminoglycoside renal clearance, noted mainly in preterm infants. Oral neomycin is poorly absorbed and intranasal ketorolac has modest systemic exposure, so relevance is small.
What this interaction means in plain words
Ketorolac intranasal and Neomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
NSAID-related reduction in renal perfusion lowers aminoglycoside clearance.
What to do
No routine action; monitor renal function if neomycin absorption is likely or in neonates.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Neomycin
- Amikacin + Neomycin Major
- Amphotericin b deoxycholate + Neomycin Major
- Capreomycin + Neomycin Major
- Cidofovir + Neomycin Major
- Colistin + Neomycin Major
- Ethacrynic acid + Neomycin Major
Frequently asked questions
Can I take Ketorolac intranasal with Neomycin?
MediHelp rates the interaction as minor. Ketorolac intranasal and Neomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs can reduce aminoglycoside renal clearance, noted mainly in preterm infants. Oral neomycin is poorly absorbed and intranasal ketorolac has modest systemic exposure, so relevance is small.
How serious is the interaction between Ketorolac intranasal and Neomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action; monitor renal function if neomycin absorption is likely or in neonates.
What other medicines interact with Neomycin?
MediHelp also lists interactions of Neomycin with, for example, Amikacin, Amphotericin b deoxycholate, Capreomycin. The full list is on the Neomycin page.
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