Drug interactions
Ketorolac intranasal + Pralatrexate
Severity: Moderate
Ketorolac intranasal and Pralatrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as ketorolac can reduce renal clearance of pralatrexate and impair renal function, raising pralatrexate exposure and toxicity including mucositis and myelosuppression.
What this interaction means in plain words
Ketorolac intranasal and Pralatrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Reduced renal tubular secretion and NSAID-related decline in renal perfusion decrease pralatrexate clearance.
What to do
Avoid ketorolac where possible and use paracetamol instead. If needed, monitor renal function, mucositis and blood counts.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pralatrexate
Frequently asked questions
Can I take Ketorolac intranasal with Pralatrexate?
MediHelp rates the interaction as moderate. Ketorolac intranasal and Pralatrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as ketorolac can reduce renal clearance of pralatrexate and impair renal function, raising pralatrexate exposure and toxicity including mucositis and myelosuppression.
How serious is the interaction between Ketorolac intranasal and Pralatrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ketorolac where possible and use paracetamol instead. If needed, monitor renal function, mucositis and blood counts.
What other medicines interact with Pralatrexate?
MediHelp also lists interactions of Pralatrexate with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Brexucabtagene autoleucel. The full list is on the Pralatrexate page.
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