Drug interactions
Ketorolac intranasal + Prednisone
Severity: Moderate
Ketorolac intranasal and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids combined with NSAIDs raise the risk of gastric and duodenal ulceration and gastrointestinal bleeding. Intranasal ketorolac gives systemic exposure, so the risk is real though likely lower with short courses.
What this interaction means in plain words
Ketorolac intranasal and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive gastrointestinal mucosal injury: NSAID prostaglandin inhibition combined with corticosteroid impairment of mucosal healing.
What to do
Keep ketorolac to the shortest course and lowest dose, and consider a proton pump inhibitor in patients at high GI risk. Counsel patients to report black stools or abdominal pain.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Ketorolac intranasal with Prednisone?
MediHelp rates the interaction as moderate. Ketorolac intranasal and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids combined with NSAIDs raise the risk of gastric and duodenal ulceration and gastrointestinal bleeding. Intranasal ketorolac gives systemic exposure, so the risk is real though likely lower with short courses.
How serious is the interaction between Ketorolac intranasal and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep ketorolac to the shortest course and lowest dose, and consider a proton pump inhibitor in patients at high GI risk. Counsel patients to report black stools or abdominal pain.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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