Drug interactions
Ketorolac intranasal + Tolazamide
Severity: Minor
Ketorolac intranasal and Tolazamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs have occasionally been reported to potentiate sulfonylurea hypoglycemia. With intranasal ketorolac, short-term use and modest systemic exposure make a meaningful effect unlikely.
What this interaction means in plain words
Ketorolac intranasal and Tolazamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible protein-binding displacement or prostaglandin-related effects on insulin secretion; not well established.
What to do
No routine change is needed; check blood glucose if the patient reports hypoglycemia symptoms during the course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Ketorolac intranasal with Tolazamide?
MediHelp rates the interaction as minor. Ketorolac intranasal and Tolazamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs have occasionally been reported to potentiate sulfonylurea hypoglycemia. With intranasal ketorolac, short-term use and modest systemic exposure make a meaningful effect unlikely.
How serious is the interaction between Ketorolac intranasal and Tolazamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; check blood glucose if the patient reports hypoglycemia symptoms during the course.
What other medicines interact with Tolazamide?
MediHelp also lists interactions of Tolazamide with, for example, Disopyramide, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolazamide page.
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