Drug interactions
Ketorolac intranasal + Tolbutamide
Severity: Minor
Ketorolac intranasal and Tolbutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can potentiate sulfonylurea effect and cause hypoglycemia, mainly through protein binding or CYP2C9 competition. With intranasal ketorolac, systemic exposure is lower than oral or injectable but still present, so the effect is likely small.
What this interaction means in plain words
Ketorolac intranasal and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible displacement from plasma protein binding and competition for CYP2C9; not firmly established for ketorolac.
What to do
No routine change is needed for short-term use; advise patients to watch for hypoglycemia symptoms and check glucose if symptomatic.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Ketorolac intranasal with Tolbutamide?
MediHelp rates the interaction as minor. Ketorolac intranasal and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs can potentiate sulfonylurea effect and cause hypoglycemia, mainly through protein binding or CYP2C9 competition. With intranasal ketorolac, systemic exposure is lower than oral or injectable but still present, so the effect is likely small.
How serious is the interaction between Ketorolac intranasal and Tolbutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed for short-term use; advise patients to watch for hypoglycemia symptoms and check glucose if symptomatic.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
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